Chemical Carcinogenesis Testing and Related Issues - Subchronic Studies and Related Issues

Abstract

The prechronic studies in the context of their use in the carcinogenesis bioassay program of the National Toxicology Program (NTP) were examined in terms of the general use and design of this type of study as a toxicological tool. The purpose of the subchronic study is to predict the toxic effects which may occur in the animals during the chronic administration of the test agent. Based on the subchronic observations, a predicted is made of the maximum tolerated dose (MTD) that can be given to the animals in the chronic study without producing unwanted side effects.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 1985
Accession Number
ADP005144

Entities

People

  • Andrew Sivak

Organizations

  • Arthur D. Little

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alkenes
  • Bioassay
  • Body Weight
  • Cancer
  • Chemical Synthesis
  • Chemistry
  • Clinical Laboratories
  • Data Storage Systems
  • Databases
  • Ecology
  • Environmental Protection
  • Kinetics
  • Medical Personnel
  • Neoplasms
  • New York
  • Organic Chemistry
  • Toxicity

Readers

  • Computational Modeling and Simulation
  • Environmental Engineering.
  • Naval Engineering and Maritime Security