An approach in determining the effects of psychostimulants on cerebral electrical activity in the non-human primate(Une Approche Des Effets De Psychostimulants Sur L'Activite Electrique Cerebrale Chez Le Primate Non Humain),
Abstract
The purpose of this work was to determine the very original properties of this new psychostimulant agent against two other conventional stimulants; viz., caffeine and d-amphetamine. (The drug d-amphetamine is still given to aircrew in France; and, of course, it has well-known side effects.) The new drug was studied in our laboratory in the non-human primate, the rhesus monkey. At the dosage indicated -- 25 mg/kg -- there were no side effects in the performance of the animal nor in its vegetative parameters; viz., in blood pressure and heart rate. The main effect of the drug was that it kept the animal awake, though not as a stimulant. This effect would give the impression that the drug is not comprised of an amphetamine-like type of molecule. It's an action which is quite specific - as based on other studies in apes and rats -- in that is appears to work on post-synaptic brain centres at that level of dosage. Of course, at a higher dosage it would probably have a doping effect. (js)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1988
- Accession Number
- ADP006106
Entities
People
- C. Milhaud
- D. Lagarde
Organizations
- AGARD