Genetic Determinants of Hepatocarcinogenesis in the B6C3F1 Mouse,
Abstract
The B6C3F1 mouse is highly susceptible to the induction of liver tumors because of the contribution of a specific gene, an allele of the hepatocarcinogen sensitivity (Hcs) locus, inherited from its C3H inbred parent. This gene affects the rate of growth of preneoplastic hepatic lesions and results in the more rapid appearance of hepatic neoplasms in mice carrying the C3H allele in comparison to mice homozygous for the resistant C57BU6 allele. The Hcs locus also acts synergistically with at least one class of chemical tumor promoters, the halogenated aromatic hydrocarbons. Because of this genetic promotion of hepatocarcinogenesis, B6C3F, mice are more sensitive to liver tumor induction by both genotoxic and nongenotoxic carcinogens.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1990
- Accession Number
- ADP006363
Entities
People
- Christopher J. Kemp
- Marie Hanigan
- Norman R. Drinkwater
Organizations
- University of Wisconsin–Madison