Heterogeneity of Enzyme-Altered Foci in Rat Liver,

Abstract

Enzyme-altered foci (EAF) in liver are assumed to be precursor lesions for tumors in this organ. Results obtained with selected hepatocarcinogens which produce lesions of differing phenotype and growth behavior indicate that not the total number of enzyme-altered cells, but rather, the proliferation of individual cell clones is of major importance for additional changes leading to malignancy. Analyses including multiple marker enzymes demonstrate a relationship between foci phenotype and proliferation. The inducibility of certain down-regulated enzymes in EAF indirectly suggests disturbances in the expression of regulatory genes such as protooncogenes. Data on Ha-ras and c-myc protooncogene expression in EAF are presented.

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1990
Accession Number
ADP006365

Entities

People

  • Albrecht Buchmann
  • Dale Pearson
  • Martina Schulte
  • Michael Schwarz
  • Werner Kunz

Organizations

  • German Cancer Research Center

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Cancer
  • Genes
  • Genetic Phenomena
  • Genetic Structures
  • Genetics
  • Heterogeneity
  • Neoplasms
  • Phenotypes
  • Precursors
  • Toxicology

Fields of Study

  • Biology

Readers

  • European Security and Defence Policy (ESDP).
  • Molecular Biology and Genetics