Interfacing Physiologically-Based Pharmacokinetic Modeling and Simulation Systems
Abstract
The graphical user interface of a physiologically-based pharmacokinetic (PB PK) modeling and simulation system developed for the Macintosh computer is described. The user interactively specifics: (1) the anatomical structure of the model (tissues) and the anatomical structure of each tissue; (2) physiological relationships; (3) transport characteristics; (4) thermodynamic properties of the substance. The interface utilizes four independent interactive windows: Model, Parameter, Kinetics, and Solution. The user selects tissues for the model and an exposure route from a flow diagram consisting of nine different tissues and four possible routes of exposure, or from a menu. Assumptions limiting the rate of mass transfer can be specified for each tissue. Parameters for each tissue, as well as dosage parameters, are entered via dialog boxes. This method of specifying the model parameters encourages What if ... ? scenarios. The model is cast in an S-system format for ease of solution and for added flexibility in simulating inherently nonlinear biological systems. The system generates a steadystate solution, which can be plotted as multiple tissue concentration-time curves on a configurable graph. The data files can be exported to other graphics and statistics packages. The pictorial flow diagram, a table of all tissue parameter values, the steady-state solution set, and the graphic plots can be printed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1992
- Accession Number
- ADP007117
Entities
People
- Derek B. Janszen
- M. C. Miller Iii
Organizations
- Medical University of South Carolina