A Conformational Study of Achatin-I, an Endogenous Neuropeptide Containing a D-Amino Acid Residue,

Abstract

Achatin-I was isolated from the suboesophageal and cerebral ganglia of the African giant snail(Achatina fulica Ferussac), and evoked a potent neuroexcitatory effect. The amino acid sequence of achatin-I is H-Gly-D-Phe-Ala-Asp-OH, and it is the first example of an endogenous neuropeptide having a D-amino acid residue. From the same ganglia, an L-Phe derivative of achatin-I was also isolated, and termed as achatin-II.

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1992
Accession Number
ADP008343

Entities

People

  • Hiroyuki Minakata
  • Kyosuke Nomoto
  • Takashi Iwashita
  • Toshimasa Ishida
  • Yoshimi Kamatani

Organizations

  • Osaka University

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Amino Acids Peptides And Proteins
  • Biomolecules
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Massachusetts
  • Peptides
  • Sequences

Readers

  • Molecular and Cellular Biochemistry
  • Neuroscience