The Topochemical Basis for Morphiceptin and Dermorphin Bioactivity

Abstract

Morphiceptin (Tyr1-Pro2-Phe3-Phe4-NH2) and dermorphin (Tyr1-D-Ala2- Phe3-Gly4-Tyr5-Pro6-Ser7-NH2) are highly microns-receptor selective peptide opioids. Since the biologically important Tyr1 and Phe3 are joined by a single amino acid, the second residue plays a significant role to orient these residues in the correct array necessary for bioactivity.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1992
Accession Number
ADP008346

Entities

People

  • Murray Goodman
  • Seonggu Ro
  • Toshimasa Yamazaki

Organizations

  • University of California, San Diego

Tags

DTIC Thesaurus Topics

  • Amines
  • Amino Acids
  • Availability
  • California
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Isomers
  • Massachusetts
  • Methylation
  • Peptides
  • Stereoisomers
  • Symposia
  • Topology
  • Universities

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biochemistry