Theory for Protein Aggregation,

Abstract

Proteins often aggregate to form biologically inactive precipitates. To better understand this problem, we have developed a mean-field lattice statistical mechanics theory for the equilibrium between native, denatured, and aggregated states of proteins and other random copolymers of hydrophobic and hydrophilic monomers in aqueous solution.

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1992
Accession Number
ADP008359

Entities

People

  • Darwin O. Alonso
  • Dirk Stigter
  • Gregg B. Fields
  • Ken A. Dill

Organizations

  • University of California, San Francisco

Tags

DTIC Thesaurus Topics

  • Aqueous Solutions
  • Chemistry
  • Copolymers
  • Hydrophilic Properties
  • Hydrophobic Properties
  • Massachusetts
  • Mechanics
  • Polymer Chemistry
  • Precipitates
  • Statistical Mechanics

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biochemistry
  • Polymer Science and Technology
  • Theoretical Analysis.

Technology Areas

  • Microelectronics