Conformational Studies of Boc-L-Pro-L-Pra-Gly-OMe by X-Ray,
Abstract
L-Propargylglycine (L-Pra) has been revealed to be a natural occuring antimetabolite of methionine and leucine. Its synthetic racemate is also a powerful inhibitor of microbial growth. In search of certain enzyme inactivators. L-Pra was incorporated into dipeptides that resulted in strong suicidal substrates for microorganisms. Sinc procollagen consists mainly of the Pro-X-Gly unit which is post-translationally hydroxylated by the enzyme prolyl-4-hydroxylase (when X=Pro), we replaced X by L-Pra and studied the interaction of the resulting tripeptide with the enzyme. The synthesized peptide was characterized by NMR and mass spectrometry and its crystal structure was established by X-ray diffraction analysis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1992
- Accession Number
- ADP008368
Entities
People
- B. Hemmasi
- E. Bayer
- H. Willisch
- W. Hiller
Organizations
- University of Tübingen