D-Amino Acid Scan of Endothelin,
Abstract
Endothelin-1 (ET) belongs to a family of newly discovered peptides with potent vasoconstrictor properties, probably implicated in the pathophysiology of hypertension, renal failure, vasospasm and other disease states. Here we report a systematic approach based on single-point D-amino-acid substitution of the non-cysteinyl residues.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1992
- Accession Number
- ADP008423
Entities
People
- J. P. Tam
- J. W. Zhang
- M. Galantino
- R. De Castiglione
- Wenxin Liu
Organizations
- The Rockefeller University