Boc-CCK-4 Derivatives Containing Side Chain Ureas and Amides as Potent and Selective CCK-A Receptor Agonists,
Abstract
Analysis of singly substituted ureas revealed that greatest CCK-A potency and selectivity were achieved upon substitution of the phenyl ring at the 2 position. The Me- and Cl-substituted analogs possessed greater binding affinity than their respective CF 3-substituted derivative.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1992
- Accession Number
- ADP008424
Entities
People
- C. W. Lin
- H. Kopecka
- K. E. Asin
- K. Shiosaki
- R. A. Craig