Structure-Activity of C-Terminal Modified Analogs of Ac-CCK-7,
Abstract
As part of our overall program to develop orally active CCK mimetics for use as appetite suppressants, we require detailed knowledge of the role played by each structural element of CCK at its receptors. Previous SAR with CCK analogs indicates that and intact C-terminal carboxamide is required for full agonist activity while the aromatic ring on the C-terminal phenylalanine may be substituted by lower alkyl or cycloalkyl moieties with only modest effects on binding to either the CCK-A or CCK-B receptors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1992
- Accession Number
- ADP008425
Entities
People
- I. Kulesha
- J. W. Tilley
- R. Sarabu
- S. J. Shiuey
- W. Danho