EGF-Receptor Binding Peptides from Transforming Growth Factor Alpha (TGF Alpha): Evidence for a Multi-Domain Interaction,

Abstract

TGF alpha is a small protein which can bind to, and activate, epidermal growth factor receptors (EGF-R) on the surface of epithelial, mesenchymal and a range of cancer cells, causing the initiation of DNA synthesis and subsequent division. Despite intensive efforts using site-directed mutagenesis, synthetic peptide fragments, and determination of the secondary and tertiary folding of TGF alpha in solution, the role and importance of many structural features in mediating EGF-R activation remain ill-defined. We have assayed the ability of EGF-R to bind to peptide fragments of TGF alpha.

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1992
Accession Number
ADP008426

Entities

People

  • Audrey Richter
  • Clement Higginbotham
  • Donna E. Davies
  • J. Wayne Conlan
  • Michael E Ward

Organizations

  • University of Florida

Tags

DTIC Thesaurus Topics

  • Biomolecules
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Growth Factors
  • Massachusetts
  • Peptide Growth Factors
  • Peptides

Fields of Study

  • Medicine

Readers

  • Breast cancer cell signaling and growth regulation.
  • Immunology and Pathology
  • Molecular and Cellular Biochemistry