A Peptide Model for the Heparin Binding Site on Antithrombin III,
Abstract
The 432 amino acid glycoprotein Antithrombin III (ATIII) regulates several key steps in the blood clotting cascade by inhibiting serine proteases such as thrombin and factor X sub a. The rate by which ATIII inhibits these enzymes is accelerated 1000-fold by binding to a specific polysaccharide sequence within the carbohydrate chains of heparin. Heparin is a heterogeneous polysulfated proteoglycan, the saccharide portion of which is commonly prescribed in the treatment of thrombosis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1992
- Accession Number
- ADP008428
Entities
People
- Annemarie I. Coffman
- Peter T. Lansbury Jr.
Organizations
- Massachusetts Institute of Technology