Syntheses and Chemotactic Activities of 2,3-Methanophenylalanine3Chemotactic Peptides,

Abstract

A family of N-formyl Met peptides is known to have chemotactic activity for neutrophils and macrophages, and neutrophil activating potency. The SAR of these peptides have been well-documented. Recently structures of to of these peptides have been well-documented. Recently structures of two fMLF (HCO-Met-Leu-Phe-OH, also known as fMLP) receptor proteins were determined. However, analogs which can discriminate among fMLF receptor subtypes has not yet been obtained.

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1992
Accession Number
ADP008429

Entities

People

  • Charles H. Stammer
  • Hiroaki Kodama
  • Kazuyasu Sakaguchi
  • Masaya Miyazaki
  • Michio Kondo

Organizations

  • National Institutes of Health

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Biological Sciences
  • Cells (Biology)
  • Chemistry
  • Connective Tissue Cells
  • Continents
  • Geographic Regions
  • Hemic And Immune Systems
  • Immune System
  • Macrophages
  • Massachusetts
  • Mononuclear Phagocyte System
  • Myeloid Cells
  • Phagocytes

Fields of Study

  • Biology
  • Chemistry

Readers

  • Immunology and Pathology
  • Molecular and Cellular Biochemistry