Studies of Dimeric fMLF with High Chemotactic Activities,
Abstract
A number of peptides and proteins such as C5a, fMLF (also known as fMLP) and Interleukin 8 exhibit biological activity as chemoattractants in inflammatory sites. In addition to the directed migration of cells, these stimulants induce a variety of coordinated biochemical and cellular responses in neutrophils and macrophages. Among these chemoattractants, fMLF is the most widely investigated. In order to elucidate the relationship between biological activity and receptor systems, the effective ligands which discriminate the receptor subtypes have been required. Dimeric analog often showed remarkable activity and high receptor selectivity for the opiate receptors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1992
- Accession Number
- ADP008430
Entities
People
- Hiroaki Kodama
- Jiangin Fan
- Masaya Miyazaki
- Michio Kondo
- Teruo Watanabe
Organizations
- Saga University