A Melanotropic Peptide Induces Pigmentation (Tanning) of Human Skin,
Abstract
We have designed and biologically characterized an analog of alpha-melanocyte stimulating hormone with the following structure: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2. The hormone analog is superpotent, prolonged acting and is resistant to inactivation by sera and proteolytic enzymes. This peptide stimulates various pigmentation in the mouse when administered topically or when injected subcutaneously. Following FDA and Human Subjects Committee approval, the peptide was delivered by subcutaneous injection to human volunteers in a phase-I clinical trial.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1992
- Accession Number
- ADP008432
Entities
People
- M. E. Hadley
- N. Levine
- R. T. Dorr
- S. D. Sharma
- V. J. Hruby
Organizations
- University of Arizona