Conformationally Constrained Glucagon Analogs: New Evidence for the Conformational Features Important to Glucagon-Receptor Interactions,
Abstract
Structure-activity studies of glucagon suggest that the 9 to 14 region of glucagon is important for its biological activity. On the other hand, design, synthesis and conformational studies of the glucagon analog glucagon indicated that its superagonist activity was the result of enhanced alpha-helical potential in the C-terminal region. To further examine the conformational features of glucagon important for its biological activity, we have designed and synthesized four cyclic, conformationally restricted analogs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1992
- Accession Number
- ADP008436
Entities
People
- Dev Trivedi
- Mara Siegel
- Victor J. Hruby
- Ying Lin
Organizations
- University of Arizona