CCK Heptapeptide Analogs: Effect of Conformational Restrictions and Standard Modifications on Selectivity and Activity at CCK-A and CCK-B Receptors,
Abstract
Cholecystokinin (CCK) is a peptide hormone involved in the regulation of gall bladder contraction, pancreatic enzyme secretion, and gastric emptying. Exogenous CCK or its close analogs suppress feeding in a number of species, including man, and endogenous CCK may have a role in the normal satiety response. As part of our effort toward development of anorectic agents based on CCK, we investigated the structural and conformational requirements for activity at CCK-A and CCK-B receptor subtypes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1992
- Accession Number
- ADP008437
Entities
People
- C. W. Lin
- David G. Witte
- Mark W. Holladay
- Michael D. Tufano
- Michael J. Bennett