Detection and Tumor-Associated MUC-2 Epitopes by Means of Monoclonal Antibodies and Synthetic Peptides,
Abstract
Mucins, the main component of mucus synthesized by glandular epithelial cells, are high molecular weight glycoproteins rich in Thr, Ser, Pro, Ala and Gly. 60-80% of their mass is constituted by carbohydrates O-glycosidically linked to hydroxy amino acids. Tumors derived from glandular epithelia are characterized by aberrant mucin glycosylation patterns which lead to the exposure of epitopes (peptide and carbohydrate) that are normally cryptic. Several genes encoding human mucins have been characterized and shown to have as a common feature the presence of tandem repeats of approximately 60 bp which are rich in codons encoding hydroxy amino acids.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1992
- Accession Number
- ADP008438
Entities
People
- C. De Bolos
- D. Andreu
- F. X. Real
- G. Gambus
- G. Jodas
Organizations
- University of Barcelona