Synthesis and Biological Activity of Heteroalkyl Lipidic Amino Acids,
Abstract
S-Adenosylmethionine is the major methyl donor in biological processes. It is involved in lipid, steroid, protein, nucleic acid and catecholamine methylations. Phospholipid methylation in particular has been implicated in receptor mediated processes in many cell lines. It was reported that phosphatidylethanolamine (PE) molecules in the presence of fatty amino acid moieties are preferentially methylated. S-Adenosylhomocysteine is an endogenous inhibitor of biological methylation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1992
- Accession Number
- ADP008441
Entities
People
- Alfred N. Fonteh
- Esther Del Olmo
- Istvan Toth
- William A. Gibbons
Organizations
- University of London