Antagonist and Agonist Activities of Synthetic Peptide Fragments of g-CSF and their Protein Conjugates,
Abstract
Granulocyte-colony stimulating factor (g-CSF) is an 18-22 kDa glycoprotein which specifically stimulates the formation of granulocyte progenitor colonies in vitro and increases neutrophil, monocyte, and eosinophil populations in a dose-dependent manner in vitro. In an epitope-mapping study undertaken in our laboratories, a Hopp and Woods hydropathic profile of g-CSF identified a series of peptide fragments as likely candidates for generating g-CSF cross-reactive antibodies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1992
- Accession Number
- ADP008442
Entities
People
- Jeffrey T. Laydon
- Joanne S. Silvestri
- John C. Lee
- Pradip K. Bhatnagar
- Stephen M. Locastro