Structure-Activity of TRP Modified Analogs of Ac-CCK-7,
Abstract
The analogs were synthesized using SPPS. Receptor binding of the CCK-A and CCK-B receptor subtypes was determined using solubilized membrane preparations from rat pancreatic tissue and bovine striatum, respectively. Compounds were also evaluated for their ability to suppress food intake in a meal-fed rat model.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1992
- Accession Number
- ADP008443
Entities
People
- I. Kulesha
- J. Swistok
- J. Tilley
- S. J. Shiuey
- W. Danho