The Regulation of G Protein by Substance P-Related Peptide: Inhibition of the Effects of Mastoparan and receptor,

Abstract

Various amphiphilic peptides including mastoparan and substance P (SP) catalyze the activation of GTP-binding regulatory proteins (G proteins). The mechanism of the activation has been studied most intensively in the case of mastoparan, and it has been shown that mastoparan activities G proteins by a mechanism similar to that used by G protein- coupled receptors. Mastoparans are known to cause secretion from various types of cells, including histamine from mast cells, and to cause a transient increase of intracellular Ca(2+).

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1992
Accession Number
ADP008447

Entities

People

  • Eisuke Munekata
  • Hidehito Mukai
  • Tsutomu Higashijima
  • Yoichiro Abe

Organizations

  • University of Texas Southwestern Medical Center

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Histamine
  • Inhibition
  • Massachusetts
  • Mast Cells
  • Organic Chemistry
  • Regulations
  • Secretion

Fields of Study

  • Biology

Readers

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  • Molecular and Cellular Biochemistry