SAR Studies of Cycloseptide: Effects of Cyclization and Charge at Position 6,
Abstract
We have recently formulated a new concept of medium and long range cyclization called backbone cyclization. In this approach, conformational constraints are conferred on a peptide by linking omega-substituted alkyl chains replacing N(alpha) and/or C(alpha) hydrogens in a peptide backbone. Backbone cyclization, which is divided into N-backbone and C-backbone Cyclizations, allow for new modes of cyclization in addition to the classical modes which are limited to cyclization through the side chains and/or the amino or carboxyl terminal groups.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1992
- Accession Number
- ADP008451
Entities
People
- C. Gilon
- D. Halle
- G. Byk
- M. Chorev
- Z. Selinger
Organizations
- Hebrew University of Jerusalem