Novel Trifluoromethyl-Containing Peptides as Inhibitors for Angiotensin- Converting Enzyme and Enkephalin-Aminopeptidase

Abstract

There is an increasing interest in the incorporation of fluoroamino acids as well as fluoro-isosteres into physiologically active peptides and enzyme inhibitors. We have been interested in the unique lipophilicity, size and polarity of trifluoromethyl (TFM) group. In the present study, we examined the effects of TFM on the activity and specificity of angiotensin-converting enzyme (ACE) inhibitors and enkephalin analogs.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1992
Accession Number
ADP008538

Entities

People

  • Bela Pete
  • Fabian Jameison
  • Iwao Ojima
  • John D. Conway
  • Koji Kato

Organizations

  • Stony Brook University

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Angiotensin
  • Cerebrum
  • Chemical Synthesis
  • Chemistry
  • Enzyme Inhibitors
  • Inhibition
  • Inhibitors
  • Methionine
  • New York
  • Rodents

Fields of Study

  • Chemistry

Readers

  • Aquatic Ecology
  • Molecular and Cellular Biochemistry