Analogs of Growth Inhibitors of Hemopoietic and Epidermal Cells,

Abstract

Growth factors and inhibitors play a pivotal role in the homeostasis of organisms. Most of these regulators of cell proliferation are polypeptides of high molecular mass and low specificity. Both their availability and clinical applicability are limited. Recently isolation, structure determination and preliminary biological studies of some cell proliferation inhibitory oligopeptides were reported. Among others they include Glp-Glu-Asp-Ser-Gly (EI) epidermal and Glp-Glu-Asp-Cys-Lys (HI) hemoregulatory inhibitors. The remarkable structural similarity and high specificity of these oligopeptides prompted us to study structure-activity relationships of HI and EI.

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1992
Accession Number
ADP008541

Entities

People

  • A. Balazs
  • I. Schoen
  • L. Kisfaludy
  • T. Szirtes

Organizations

  • Hungarian Academy of Sciences

Tags

DTIC Thesaurus Topics

  • Availability
  • Biomolecules
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Growth Factors
  • Homeostasis
  • Inhibitors
  • Massachusetts
  • Peptides
  • Regulators

Fields of Study

  • Chemistry

Readers

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