Peptide Inhibitors of Matrix Metalloproteases,
Abstract
Inhibitors of mammalian collagenases and gelatinase have considerable promise for therapy of arthritis, pseudomonas infections, and tumor metastasis. We synthesized effective peptide inhibitors with IC50 values near or below 1 nM against mammalian Type I collagenase and Type IV collagenase (gelatinase). We now focused on (a) demonstration of selectivity vs. other naturally occuring metalloproteases; and (b) improved biostability and oral activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1992
- Accession Number
- ADP008549
Entities
People
- A. F. Spatola
- K. Darlak
- K. Nijhawan
- M. Anzolin
- S. Pegoraro
Organizations
- University of Louisville