Issues Surrounding Comparative Risk Assessments of Operational Materials: An Example with Air Force Hydraulic Fluids,
Abstract
New products entering today's marketplace frequently undergo toxicity testing to determine the potential risks they pose to exposure people. Not commonly, these products undergo more extensive testing than materials that have been in use, are often products intended for the same end use, and may have completely different toxicity profiles in test animals. Differences in the nature of the products, the amount of toxicity data available, and differing target tissues for the materials complicate comparisons of the potential human health hazards of various products. Especially difficult interpretive issues arise when new products cause effects in experimental animals that, for compelling biological reasons, are not expected to occur in humans or other primates. Some of these issues in comparative health risk assessment of new materials are highlighted by Air Force-sponsored studies of a candidate nonflammable hydraulic fluid based on polychlorotrifluoroethylene oligomers. This material has performance characteristics similar to hydrocarbon- and phosphate ester-based fluids that are currently in use
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1993
- Accession Number
- ADP008719
Entities
People
- David R. Mattie
- Harvey J. Clewell Iii
- Melvin E. Andersen
Organizations
- University of Wisconsin–Madison