Effect of S-Mustard on Stress Response
Abstract
The cellular stress response is an universal defence mechanism, by which socalled stress proteins are induced and expressed on the expense of the constitutive protein expression, following cellular exposure to stress effectors of various kind including heat shock. The heat shock response in mononuclear human cells was investigated with respect to any effect of sulfur mustard on this response. The results showed a strong, inhibitory effect on the heat shock response in sulfur mustard (0,1 mM) poisoned cells, which included strong inhibition of both stress protein and constitutive protein synthesis. The results further showed that this effect was strongly dependent on the order of mustard poisoning and heat shock, since heat shocked cells exposed to sulfur mustard displayed a normal heat shock response. The results indicate a special mechanistic coupling between stress response and sulfur mustard poisoning, which might have both biochemical (transcriptional/translational) as well as physiological consequenses.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 13, 1993
- Accession Number
- ADP008782
Entities
People
- Sigrun H. Sterri
Organizations
- Norwegian Defence Research Establishment