Solubility and Solution Stability of WR-272677, an Oral Anticyanide Candidate
Abstract
WR-272677, p-hydroxylaminoheptanophenone, has protected mice against cyanide challenge at the Battelle Laboratory. Single dose oral and intravenous pharmacokinetic and pharmacodynamic studies performed in the Division of Experimental Therapeutics at the Water Reed Army Institute of Research have shown this compound to be a potent former of methemoglobin, or ferrihemoglobin, which selectively binds cyanide. One of the steps in the development of this anticyanide agent is to determine its solubility and solution stability. The apparent room-temperature solubilities of WR-272677AB in aqueous media, ethanol, polyethylene glycol (PEG) 400, and aqueous ethanol have been determined. WR-272677AB is insoluble (<O.l mg/mL) in the aqueous media and aqueous alcohol, but is freely soluble (-400 mg/mL) in either ethanol or PEG 400. WR-272677AB dissolved in ethanol or PEG 400 under ordinary atmospheric conditions rapidly decomposes, mainly to p-azoxyheptanophenone. In the absence of molecular oxygen, however, ethanol solutions of WR-272677AB are stable for at least 24 hours.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 13, 1993
- Accession Number
- ADP008852
Entities
People
- John Pick
- Lori L. Olson
- Peter Lim
- William Y. Ellis
Organizations
- SRI International