Slow, Tight-Binding Inhibition of Acetylcholinessterase (AChe) By Aryl trifluoromethyl Ketones.

Abstract

Acetylcholinesterases from Torpedo californica (TC-AChE) and Electrophorus electricus (EE-AChE) are inhibited by aryl trifluoroketones, m-XPhCOCF3. Trifluoroacetophenone (TFA; X = H) is a rapid competitive inhibitor; K(i) values are 210 nM and 520 nm for respective inhibitions of EE-AChE and TC-AChE. m-Dimethylamino trifluoroacetophenone (DMTFA, X = Me2N) and m-trimethylamino trifluoroacetophenone (TMTFA, X = Me3N+) are slow, tight binding inhibitors. The kinetics of inhibition by DMTFA are described.

Document Details

Document Type
Technical Report
Publication Date
May 13, 1993
Accession Number
ADP008853

Entities

People

  • B. P. Doctor
  • D. M. Quinn
  • H. Nair
  • J. Servalli
  • K. Lee

Organizations

  • University of Iowa

Tags

Communities of Interest

  • Weapons Technologies

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Fish
  • Inhibition
  • Inhibitors
  • Kinetics
  • Maryland

Fields of Study

  • Chemistry

Readers

  • Neurotoxicology
  • Organic Chemistry