Binding Parameters of Animal Toxins: Tetrodotoxin, Saxitoxin and Micro-Conotoxin on Na+ Potential-Dependant Channels of Rat Brain Homogenates and Slices.

Abstract

Tetrodotoxin and saxitoxin coming from a fish (fugu) and a sea dynoflagelate (alexandrium) are pharmacological tools for studying Na+ potential-dependant channels; u-conotoxin from a sea-snail shell is a short peptide (22 AA) and therefore could cross some anatomical barriers when administered by respiratory route. In such case, this toxin could eventually represent a threat. In this study, binding parameters of the three toxins were determined on rat brain homogenates and slices by autoradiography and image analysis. Some results on the toxin capability to cross respiratory system and blood brain barrier will also be presented.

Document Details

Document Type
Technical Report
Publication Date
May 13, 1993
Accession Number
ADP008880

Entities

People

  • C. Pignot
  • C. Richer
  • H. Garrigue
  • O. Bouvet
  • P. Binder

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anatomy
  • Biological Sciences
  • Blood
  • Blood-Brain Barrier
  • Body Fluids
  • Brain
  • Fluids And Secretions
  • Hemic And Immune Systems
  • Maryland
  • Respiratory System

Fields of Study

  • Biology

Readers

  • Microbial Pathology
  • Molecular and Cellular Biochemistry
  • Toxicology/Environmental Toxicology