Properties of Monoclonal Antibodies to Staphylococcal Enterotoxin B

Abstract

Our laboratory has developed some forty monoclonal antibodies to staphylococcal enterotoxin B (SEB). Ten of these antibodies have been studied intensively to determine their fine specificity and biological activity. Preliminary data suggest that some of the antibodies protect mice from a lethal challenge with SEB. Some inhibit the SEB-induced proliferation of human or mouse cells. Others inhibit the binding of SEB to human MHC class II antigens. Because T cell and monocyte activation may be important factors in the intoxication caused by SEB, we hope that correlation of in vitro and in vivo studies will give insight regarding the mechanism of protection by antibodies.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
May 13, 1993
Accession Number
ADP008885

Entities

People

  • Ching-feng Weng
  • Jack Komisar
  • James Y. Chen
  • Jeenan Tseng

Organizations

  • Walter Reed Army Institute of Research

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Antibodies
  • Antigens
  • Biological Factors
  • Biological Toxins
  • Blood
  • Cell Line
  • Cells
  • Chemistry
  • Inhibition
  • Lymphatic System
  • Lymphocytes
  • Maryland
  • Molecules
  • Peptides
  • Proteins
  • Tissues

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology