Nano-Sized 6Ofullerene-Cyclodextrin Molecules
Abstract
As 60fullerene is a very hydrophobic macromolecule, there have been a number of attempts to make it more hydrophilic for biomedical applications. By attaching hydrophilic moieties such as poly(oxyethylene)(POE) chains and cyclodextrin molecules to 60fullerene, novel water-soluble and biocompatible materials have been successfully prepared 1,2. The synthesis of novel macrocyclic fullerene conjugates which are water-soluble is reported. The telechelic fullerene derivatives have been prepared via addition reaction of POE-based arms with covalently bonded beta-cyclodextrin (CD) to 60fullerene. To this end, a mono-tosylated CD derivative has been prepared in pyridine and then reacted with an amino- functional POE in the presence of triethylamine. The subsequent reaction of 60fullerene with the hydrophilic POE-conjugated CD-derivative yielded the macrofullerene after separation and purification procedures. The macrocyclic 60fullerene derivatives obtained were soluble in water and characterized by UV-VlS and FT-IR spectroscopy as well as light scattering measurements and thermogravimetric analysis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2001
- Accession Number
- ADP012139
Entities
People
- Han-chang Kang
- Jeong-seo Park
- Kurt E. Geckeler
Organizations
- Gwangju Institute of Science and Technology