Analysis of the HI-6, HS-3 and HS-6, Influence on the Liver Methabolizing Enzyme Systems
Abstract
At the present stage of the therapy and prophylactics of the poisonings with organophosphorous compounds (OPC), the reactivators of the cholinesterase take an important place. However, the application of these compounds is always combined with some other drugs. Therefore, it is necessary to know the possibilities for influence of the drug metabolism by the reactivators, as well their own metabolism and pharmacokinetics. This type of research is very necessary, when the newly synthesized compounds are concerned. Our research has shown that the classical reactivator of the cholinesterase Toxogonin, causes decrease of microsomal ethylmorphin N-demethylation activity, which probably was connected to the coincident loss of cytochrome P450 (Dishovsky, et al, 1989). The reactivators TMB-4 (Trimedoxime) and Diethyxime, have a similar effect (Dishovsky, et al, 1990). In this relation, the aim of the present work was to follow changes in liver drug metabolism after in vivo treatment with some H-Oximes - HS-3, HS-6 and HI-6, which are reactivators of the cholinesterase. This is necessary, in order to optimize the conditions for the application of these antidote compounds during the therapy and prophylactics of the OPC intoxications.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2001
- Accession Number
- ADP013376
Entities
People
- Christophor Dishovsky
- Maria Kadiiska
- Petko Alov
Organizations
- Bulgarian Academy of Sciences