The Treatment of Intoxication with Selected Organophosphates and a Carbamate: Comparison of different Therapeutic Approaches
Abstract
The treatment of intoxications (2xLD5O) with sarin, DDVP and pyridostigmine (s.c.) was studied in rats. The animals were s.c. injected with toxic chemicals and treated (i.m.) with atropine, atropine and obidoxime (omitted for pyridostigmine), sodium bicarbonate (i.p.), atropine (i.m.) and sodium bicarbonate (i.p.). The start of treatment was at the onset of convulsions. Acetyleholinesterase (AChE) activity and pH in thc blood (different time intervals) and AChE activity in the frontal cortex, basal ganglia, pontomedullar part and hippocampus were determined (after death or 24 h). In intoxications with all compounds studied, rapid decrease of the blood AChE activity was observed. In the brain, AChE activity was decreased with the exception of pyridostigmine. Detected pH in the blood showed its decrease following intoxication. In sarin intoxication, the only atropine and obidoxime showed minimal therapeutic effect (lO% of survival). In case of DDVP, theraputic effect increased in following manner: bicarbonate (8O% lethality) < atropine (60% lethality) < atropine and bicarbonate (50% lethality)< atropine and obidoxime (30% lethality). Therapeutic efficacy in case of pyndostigmine was increased in the following manner: bicarbonate (80% lethality)<atropine (50% lethality) <(atropine and bicarbonate (20% lethality). The results indicate that administration of bicarbonate improves the therapy of organophosphate and pyridostigmine intoxication.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2001
- Accession Number
- ADP013398
Entities
People
- Jiri Bajgar
- Rudolf Portmann
Organizations
- Military Medical Academy