High Dose Pralidoxime (PRX) Treatment Prolongs Time to Extubation (TTE) and Increases Mortality in Paraoxon (POX) Exposed Minipigs

Abstract

Organophosphates are inhibitors of serine hydrolases. Oximes are clinically available enzyme reactivators. To determine in vivo the effect of high dose PRX use on "time-to-extubation (TTE)" and mortality as compared to identical therapy without PRX. 12 anaesthetized minipigs were used. All pigs received iv-POX (lmg/kg BW) over 50 minutes. Group one (n = 6) received conventional intensive care therapy as described previously J Appi Toxicol 18: 293 - 298. Group two (n = 6) received in addition iv-PRX 10 g ( 300 mg/kg BW). Before BASE-LINE;BL, after POX application (50 min) and then at 1,2,3,4,8 and 16 hours after POX AChE and BChE activities were measured. Statistics: rank order test; significance for p </= 0.05. In group one TTE was 7.2 +/- 4.4 h after last measurement. Mortality was 0. In group two TTE was 14.7 +/- 6.4 h after last measurement. Mortality was 4/6. Pralidoxime therapy has no beneficial effect and its use can not be recommended.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2001
Accession Number
ADP013402

Entities

People

  • A. Missler
  • C. Thyes
  • G. Petroianu
  • K. Zuleger
  • V. Ewald

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  • Heidelberg University

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  • Biomedical

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