Ebola Virus Replication in Macrophages and its Relation to the Virus Pathogeneicity
Abstract
Any infectious disease is a result of complicated interplay of both pathogen and organism factors. Identification of the most important events, which determine development of the disease is necessary for understanding of the basic mechanisms of infection. Much attention is paid to the most dangerous viral infections and Ebola hemorrhagic fever is among them. Ebola Zaire infection represents an example of the interaction of host with pathogen, when the virus kills humans and monkeys very rapidly and cruelly (1,2). Mechanisms providing such horrible abilities of Ebola virus are still unclear. It is known that Ebola virus kills monkeys in 7-9 days post-infection, while guinea pigs develop non-lethal infection (3,4). Sequential passages lead to changes of Ebola virus pathogenicity and guinea pigs began to die. This effect of passages was called "adaptation" of Ebola virus to guinea pigs, and was described in early studies (5). Analogous adaptation of the Ebola virus to adult mice by sequential passages was reported recently (6). Detailed examination of the non-lethal Ebola infection and changes of the infection in the course of passages has been not performed. Meanwhile, comparison of lethal and non-lethal forms of Ebola infection may highlight the mechanisms of pathogenicity and virulence of dangerous Ebola virus. The aim of present study was to analyze differences between fatal and non-fatal infections caused by Ebola virus, and hunt dawn the changes related with transition of non-fatal infection to fatal in experimental animals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2001
- Accession Number
- ADP013426
Entities
People
- Elena I. Ryabchikova
- Jurii N. Rassadkin
- Margarita P. Smolina