Blood Neuropathy Target Esterase as Biochemical Marker for Neuropathic Organophosphates Exposure

Abstract

In the present work we report the results of studies of possibility of application of biosensor methods to the NTE activity analysis in whole blood as well the results of OPIDN modeling in experiments on animals with acute administration of the increasing doses neuropathic OP O, O-dipropyldichlorvinylphosphate (PrDChVP) and studying the correlation between NTE inhibition in brain and blood using spectrophotometric and biosensor methods.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2001
Accession Number
ADP013428

Entities

People

  • Arkady Eremenko
  • Galina Makhaeva
  • Ilya Kurochkin
  • Larisa Sigolaeva
  • Lyudmila Zhuravleva

Tags

DTIC Thesaurus Topics

  • Albumins
  • Animals
  • Atropine
  • Biosensors
  • Blood
  • Chemical Synthesis
  • Chemistry
  • Detection
  • Electrodes
  • Inhibition
  • Measurement
  • Medical Personnel
  • Organic Chemistry
  • Organophosphates
  • Regression Analysis
  • Standards
  • Therapy

Readers

  • Computational Modeling and Simulation
  • Neurotoxicology

Technology Areas

  • Biotechnology