O-Alkyl-O-Methylchlorformiminophenyl Phosphonates Delayed Neurotoxicity Risk Assessment. In Vitro and In Vivo Studies

Abstract

In the present work we report an in vitro study of NTE and AchE inhibition by a series of model phenylphosphonates of the general formula (RO)C6H5P(O)ON-VVlCH3 (PhP), the assessment of neuropathic potential for the investigated OPs using ratios k(i)(NTE)/k(i)(AChE) and comparison the obtained results with the ratios of the median effective doses (ED(50)) for hen brain NTE and AChE inhibition obtained in vivo.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2001
Accession Number
ADP013429

Entities

People

  • Galina Makhaeva
  • Vladimir Malygin
  • Vladimir Sokolov

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Albumins
  • Animals
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemistry
  • Equations
  • Inhibition
  • Inhibitors
  • Laboratory Animals
  • Nerve Agents
  • Organophosphorus Compounds
  • Regression Analysis
  • Risk Analysis
  • Terrorism
  • Terrorists
  • Therapy

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  • Neurotoxicology