Molecularly Imprinted Polymers (MIPs) Against Uracils : Functional Monomer Design, Monomer-Template Interactions in Solution and MIP Performance in Chromatography

Abstract

The interaction of N(exp 1)-substituted uracils (cyclohexyl (1) and benzyl (2)) with three polymerisable recognition elements, the novel monomers 9-(3/4-vinylbenzyl)adenine (3) and 2,6-diamino-9-(3/4-vinyl(benzyl)purine (4) and the previously synthesized monomer 2,6- bis(acrylamido)pyridine (5), has been studied via H-1 NMR in deuterio-chloroform solution. MIPs against (2) have been prepared using each of the monomers and tested in the chromatographic mode. The effect of the number and type of hydrogen bonds formed between the templates and the functional monomers is reflected in the values of the apparent association constants obtained from the solution study and by the performance of the subsequently prepared MIPs in the chromatographic mode.

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Document Details

Document Type
Technical Report
Publication Date
Apr 05, 2002
Accession Number
ADP013598

Entities

People

  • Andrew J. Hall
  • Borje Sellergren
  • Jakob T. Mossing
  • Panagiotis Manesiotis

Organizations

  • Johannes Gutenberg University Mainz

Tags

Communities of Interest

  • Sensors

DTIC Thesaurus Topics

  • Alkenes
  • Chemical Shifts
  • Detection
  • Detectors
  • European Union
  • Flow Rate
  • Hydrogen
  • Hydrogen Bonds
  • Materials
  • Molecules
  • Nucleic Acids
  • Polymers
  • Recognition
  • Technical Information Centers
  • Template Patterns
  • Titration
  • Volume

Fields of Study

  • Chemistry

Readers

  • Operations Research
  • Polymer Science and Technology