Micromolding in Capillaries for the Generation of Molecularly Imprinted Polymer Filaments and Microstructures
Abstract
The technique of micromolding in capillary has been employed to prepare molecularly imprinted polymer microfilaments, and to pattern MIP structures on silicon wafers. The approach relies on crosslinked poly(dimethylsiloxane) that contains relief structures as a mold to define the shape and size of the imprinted polymers. This article describes the processes leading to the fabrication of free-standing MIP micromonoliths and covalently immobilized MIP microstructures on silicon wafers. The limitations of the technique are also discussed. The development of miniaturized systems for chemical, analytical and diagnostic applications has attracted great interest recently. Significant advantages in speed, efficiency and control can be gained through the application of such miniature systems in laboratory testing. Micro devices have been fabricated to perform a variety of chemical and enzymatic reactions and in chip capillary electrophoresis separation. Much effort has also been devoted to shrinking analytical instruments such as high performance liquid chromatography, combinatorial library screening system, and biosensors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 05, 2002
- Accession Number
- ADP013601
Entities
People
- Mingdi Yan
Organizations
- Portland State University