Oligonucleofide Imprinting in Aqueous Environment

Abstract

The development of synthetic receptors that recognize nucleotide bases and their derivatives is an important area of research 1-3. Applications are envisioned in separation science, biosensors, drug therapy and genetic engineering. Previously in this laboratory, we have developed a molecularly imprinted synthetic receptor for 9-ethyladenine (9-EA). The network polymer has an affinity for adenine and its derivatives with an average association constant (K(a)) of 75,000 M(-1) in CHCl3.

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Document Details

Document Type
Technical Report
Publication Date
Apr 05, 2002
Accession Number
ADP013607

Entities

People

  • Dolly Batra
  • Kenneth J Shea

Organizations

  • University of California, Irvine

Tags

DTIC Thesaurus Topics

  • Acids
  • Adenine
  • Adenosine
  • Alcohols
  • Buffers (Chemistry)
  • Chemical Synthesis
  • Chemistry
  • Materials
  • Molecules
  • Nucleotides
  • Organic Chemistry
  • Organic Solvents
  • Polymerization
  • Solvents
  • Technical Information Centers
  • Template Patterns
  • Water

Fields of Study

  • Chemistry

Readers

  • Defense Technology Research and Development.
  • Molecular and Cellular Biochemistry
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology