Molecularly Imprinted Polymers Used as Optical Waveguides for the Detection of Fluorescent Analytes
Abstract
This article demonstrates the novel approach of fabricating molecularly imprinted polymers (MIPs) as fiber optic waveguides for the detection of fluorescent analytes. Combining a polyurethane system and the soft lithography technique of micromolding in capillaries (MIMIC), polymer waveguides of 50 micrometers and 100 micrometers dimensions were patterned onto a silicon substrate. Laser coupling into small waveguide segments has been verified visually. Binding experiments using the waveguides are currently being explored. Some preliminary binding studies have been performed, however, for smaller, freestanding filaments of sizes consistent with conventionally prepared MIP particles. Using fluorimetry measurements, templated fibers of 20 micrometers dimension preferentially bound the analyte molecules by a factor of 1.5 as compared to control polymers.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 05, 2002
- Accession Number
- ADP013610
Entities
People
- Jennifer J. Brazier
- Mingdi Yan
- Scott Prahl
- Yin-chu Chen
Organizations
- Portland State University