A Highly Sensitive and Selective Surface-Enhanced Nanobiosensor

Abstract

Nanosphere lithography (NSL) derived triangular Ag nanoparticles were used to create an extremely sensitive and specific optical biological and chemical nanosensor. Using simple UV-vis spectroscopy, biotinylated surface-confined Ag nanoparticles were used to detect streptavidin down to one picomolar concentrations. The system was tested for nonspecific binding interactions with bovine serum albumin and was found to display virtually no adverse results. The extremely sensitive and selective response of the Ag nanoparticle sensor indicates an exciting use for biological and chemical sensing.

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Document Details

Document Type
Technical Report
Publication Date
Apr 05, 2002
Accession Number
ADP013612

Entities

People

  • Amanda J Haes
  • Richard P. Van Duyne

Organizations

  • Northwestern University

Tags

Communities of Interest

  • Air Platforms
  • Sensors

DTIC Thesaurus Topics

  • Alcohols
  • Biomolecules
  • Biosensors
  • Chemical Synthesis
  • Chemistry
  • Detection
  • Detectors
  • Electromagnetic Radiation
  • Materials
  • Materials Science
  • Measurement
  • Metallic Nanoparticles
  • Molecules
  • Self Assembled Monolayers
  • Surface Plasmon Polaritons
  • Surface Plasmon Resonance
  • Surface Plasmons

Readers

  • Molecular and Cellular Biochemistry
  • Nanoscale Plasmonic Nanotechnology

Technology Areas

  • Biotechnology