Wakening Substances: Caffeine (Substance eveillante: la cafeine)

Abstract

Caffeine is the most widely used psychostimulant, whose acceptance, tolerance and side effects are well known. The development of a slow released (SRC) formulation optimizes caffeine as a fatigue and sleep deprivation counter-measure. Due to its pharmacokinetic properties (delayed T (sub max) and reduced C (sub max)), a single 300 mg SRC oral dose per day is effective to maintain alertness and performance, up to 45 hours in a total sleep deprivation situation. Compared to other psychostimulants like amphetamines or modafinil, slow released caffeine offers the best ratio effectiveness/tolerance-acceptance. Therefore SRC potential use in the military is wider than these "exotic" drugs, and could benefit to military personnel submitted to sustained or continuous operations.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2002
Accession Number
ADP013768

Entities

People

  • Bruno Sicard
  • Didier Lagarde
  • Francoise Chauffard
  • Maurice Beaumont

Tags

Communities of Interest

  • Human Systems

DTIC Thesaurus Topics

  • Air Force
  • Altitude
  • Caffeine
  • Coffee
  • Cytochromes
  • Degradation
  • Depression
  • Digestive System Processes
  • Intoxication
  • Magnesium
  • Medical Personnel
  • Military Personnel
  • Molecules
  • Motivation
  • Navigation
  • Sensation
  • Technical Information Centers

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology
  • Mathematics or Statistics
  • Systems Analysis and Design