Oral Administration of Chemotherapeutic Agents Using Complexation Hydrogels

Abstract

Carriers were synthesized to target delivery of a chemotherapeutic agent bleomycin to the upper small intestine in response to the pH shift when entering the upper small intestine from the stomach. Complexation hydrogels capable of pH-responsive swelling were used to form these carriers. Hydrogel nanospheres composed of methacrylic acid (MAA) and poly(ethylene glycol) (PEG) were loaded with bleomycin. Loading of bleomycin was performed by in situ polymerization and release of bleomycin from the nanospheres was measured by UV spectrophotometry. Results showed that bleomycin release from the nanospheres was responsive to the pH of the environment surrounding the nanospheres. In addition to pH-responsive release of bleomycin, the hydrogel nanospheres are also able to enhance the permeability of an in vitro model of the intestinal epithelium. Increasing the permeability of the intestinal epithelium could aid in transport of bleomycin from the lumen of the small intestine out into the bloodstream.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2002
Accession Number
ADP014422

Entities

People

  • James Blanchette
  • Kinam Park
  • Nicholas A. Peppas

Organizations

  • Purdue University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alkenes
  • Biomedical Engineering
  • Chemical Engineering
  • Chemotherapeutic Agents
  • Electrical Resistance
  • Engineering
  • Ethylene Glycol
  • Ethylenes
  • Films
  • Gastrointestinal Tract
  • Health Services
  • Intestines
  • Materials
  • Molecular Weight
  • Monomolecular Films
  • Resistance
  • Small Intestine

Fields of Study

  • Chemistry

Readers

  • Combustion Dynamics and Shock Wave Physics.
  • European Security and Defence Policy (ESDP).
  • Immunology