Real-Time Salmonella Detection Using Lead Zirconate Titanate-Titanium Microcantilevers

Abstract

Current methods for analysis of unknown powders in suspicious packages involve sending samples to laboratory facilities where a variety of time-consuming tests are performed. We have developed and investigated the use of a lead zirconate titanate - titanium (PZT-Ti) microcantilever for in situ detection of the common food- and water-born pathogen, Salmonella typhimurium. Using a bifunctional liking molecule to immobilize antibody on the titanium surface of the microcantilever, we can directly detect salmonella cells in suspensions of differing concentration. This novel surface functionalization technique along with the sub-nanogram sensitivity of the cantilever has allowed for direct quantification of S. typhimurium cells in suspension.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2005
Accession Number
ADP019705

Entities

People

  • Irwin Chaiken
  • John-paul Mcgovern
  • Mauro Sergi
  • Wan Y. Shih
  • Wei-heng Shih

Organizations

  • Drexel University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biochemistry
  • Chemical Compounds
  • Chemistry
  • Detection
  • Detectors
  • Engineering
  • Frequency
  • Frequency Shift
  • Lead Zirconate Titanates
  • Materials
  • Materials Science
  • Mechanical Properties
  • Physical Properties
  • Quartz Crystal Microbalances
  • Resonance
  • Resonant Frequency
  • Surface Plasmon Resonance

Readers

  • Materials Science and Engineering.
  • Microbial Pathology
  • Nanoscale Plasmonic Nanotechnology