New Biological Labels Based on Functionalized YVO4:Eu Nanoparticles

Abstract

Lanthanide-ion doped oxide (YVO4:Eu) nanoparticles were synthesized as aqueous colloids and functionalized by a bioactive silane shell to be used as fluorescent biological labels. Nanoparticles functionalized with guanidinium groups were able to act as artificial toxins which specifically target Na+ channels. They were individually detectable in live cardiac myocytes. Functionalized oxide nanoparticles appear as a new interesting tool, especially attractive for long-term single-molecule tracking due to their photo-stability and long luminescence lifetime.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2005
Accession Number
ADP019711

Entities

People

  • A. Alexandrou
  • A. Mercuri
  • D. Casanova
  • D. Giaume
  • E. Beaurepaire
  • J. Boilot
  • K. Lahlil
  • M. Sauviat
  • T. Gacoin
  • V. Buissette

Organizations

  • École polytechnique

Tags

Communities of Interest

  • Advanced Electronics
  • Air Platforms

DTIC Thesaurus Topics

  • Bulk Materials
  • Cell Membrane
  • Chemistry
  • Condensed Matter Physics
  • Detection
  • Detectors
  • Diffraction
  • Electron Microscopy
  • Emission Spectra
  • Fluorescence
  • Materials
  • Materials Science
  • Microscopy
  • Nanoparticles
  • Particles
  • Spectra
  • Subatomic Particles

Fields of Study

  • Chemistry

Readers

  • Materials Science and Engineering.
  • Molecular and Cellular Biochemistry
  • Nanocomposite Materials Science

Technology Areas

  • Biotechnology